Gastrointestinal Dissolution, Supersaturation and Precipitation of the Weak Base Indinavir Sulfate in Healthy Volunteers: Fasted State, Fed State and Concomitant Proton Pump Inhibitor Use
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منابع مشابه
Single-dose pharmacokinetics of indinavir and the effect of food.
Indinavir sulfate is a human immunodeficiency virus type 1 (HIV-1) protease inhibitor indicated for treatment of HIV infection and AIDS in adults. The purpose of this report is to summarize single-dose studies which characterized the pharmacokinetics of the drug and the effect of food in healthy volunteers. Indinavir concentrations in plasma and urine were obtained by high-pressure liquid chrom...
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The purpose of this study was to investigate the influence of gastric emptying patterns, surfactants, and dosage form on the supersaturation of a poorly soluble weakly basic drug, dipyridamole, using an in vitro model mimicking the dynamic environment of the upper gastrointestinal tract, and, furthermore, to evaluate the usefulness of this model in establishing correlations to in vivo bioavaila...
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